{"id":759,"date":"2022-07-08T18:42:18","date_gmt":"2022-07-08T15:42:18","guid":{"rendered":"https:\/\/agtlab.chem.uoi.gr\/?p=759"},"modified":"2022-07-08T18:44:58","modified_gmt":"2022-07-08T15:44:58","slug":"press-greek-researchers-are-developing-a-treatment-against-the-most-aggressive-brain-tumor","status":"publish","type":"post","link":"https:\/\/agtlab.chem.uoi.gr\/?p=759","title":{"rendered":"PRESS: Greek researchers are developing a treatment against the most aggressive brain tumor"},"content":{"rendered":"

The research team at the University of Ioannina participated in the development of a new treatment that could significantly improve the effectiveness of radiation therapy in patients diagnosed with the deadliest form of brain tumor.<\/h3>\n
\n

\"\"A research team of\u00a0the Organic Chemistry Laboratory of the Chemistry Department of the University of Ioannina<\/strong>\u00a0led by Associate\u00a0Professor Mr. Andreas Tzakos<\/strong>\u00a0, in collaboration with researchers from\u00a0Imperial College London<\/strong>\u00a0and other research groups abroad, participated in a study, where it was found that\u00a0a drug that fragments the amino acid arginine,<\/strong>\u00a0made glioma tumors (GBM) more sensitive to radiotherapy.<\/p>\n

The results of this research were published in the international scientific journal\u00a0Journal of Clinical Investigation<\/strong>\u00a0<\/a>(journal impact factor 19.4 (2021)).<\/p>\n

Glioma<\/strong>\u00a0is the\u00a0most common type of high-grade primary brain tumor<\/strong>\u00a0in adults and also\u00a0the most aggressive and fatal.\u00a0<\/strong>Arginine is an amino acid used by cells to make complex molecules called proteins that perform a wide range of cellular functions.\u00a0This particular amino acid is a vital growth nutrient for a number of cancer cells and especially those that have a rapid growth rate, and therefore depriving tumors of this amino acid has been investigated as a potential anticancer strategy in various types of tumors, including glioma.<\/p>\n

The new study focused on both glioma tumors that can produce arginine and tumors that are unable to produce arginine by applying an arginine-destroying drug (ADI-PEG20) in combination with the use of radiation therapy.\u00a0The results of the study showed that\u00a0reducing the supply of arginine makes tumors more sensitive to radiation therapy<\/strong>\u00a0.\u00a0It has been observed that\u00a0removing arginine reprograms the cells of the immune system<\/strong>around the tumor increasing the likelihood that they will attack and neutralize the cancer cells.\u00a0The next steps involve investigating the safety and efficacy of using this therapeutic approach in humans in future clinical studies.<\/p>\n<\/blockquote>\n

Source: YgeiaMou (in greek)<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

The research team at the University of Ioannina participated in the development of a new treatment that could significantly improve the effectiveness of radiation therapy in patients diagnosed with the deadliest form of brain tumor. A research team of\u00a0the Organic<\/p>\n","protected":false},"author":2,"featured_media":760,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-759","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-1"],"_links":{"self":[{"href":"https:\/\/agtlab.chem.uoi.gr\/index.php?rest_route=\/wp\/v2\/posts\/759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/agtlab.chem.uoi.gr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/agtlab.chem.uoi.gr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/agtlab.chem.uoi.gr\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/agtlab.chem.uoi.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=759"}],"version-history":[{"count":4,"href":"https:\/\/agtlab.chem.uoi.gr\/index.php?rest_route=\/wp\/v2\/posts\/759\/revisions"}],"predecessor-version":[{"id":764,"href":"https:\/\/agtlab.chem.uoi.gr\/index.php?rest_route=\/wp\/v2\/posts\/759\/revisions\/764"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/agtlab.chem.uoi.gr\/index.php?rest_route=\/wp\/v2\/media\/760"}],"wp:attachment":[{"href":"https:\/\/agtlab.chem.uoi.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=759"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/agtlab.chem.uoi.gr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=759"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/agtlab.chem.uoi.gr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}